Mutagenic Evaluation of Fluoxetine and Fluoxetine-Galactomannan Complex Through the Analysis of Chromosomal Aberrations in Human Peripheral Leukocytes and Salmonella typhimurium/Microssome Assay

Objectives : The purpose of this study was to evaluate the mutagenic potential fluoxetine and fluoxetine-galactomannan. Methods Chromosomal aberration test Salmonella typhimurium/microsome mutagenicity assay. Results results showed that (250 μg/mL) can cause chromosomal breaks treated leukocytes increase frequency reversion tester strains S. typhimurium / microsome assay only at highest concentration (5 mg/mL), while encapsulated in galactomannan did not these changes (leukocytes typhimuriums strains). Conclusion In summary, a effect detectable high concentrations both eukaryotic prokaryotic models. Furthermore, fluoxetine/galactomannan complex, first moment, prevented attributed fluoxetine, emphasizing present encapsulation process be an alternative preventing effects vitro .